Exploring the Adsorptive Potential of Enterosgel: Removal of Bacterial Toxins, Bile Acids, and Pharmaceuticals

 Enterosgel, an oral intestinal adsorbent, has been investigated for its ability to remove a wide range of substances implicated in gastrointestinal disorders, including bacterial toxins, bile acids, and commonly administered drugs. The study aimed to evaluate the adsorption capacity and kinetics of Enterosgel in comparison to a standard activated carbon (Charcodote).

Results: Efficient Adsorption of Bacterial Toxins and Select Molecules

In vitro experiments demonstrated that Enterosgel effectively adsorbs bacterial toxins such as Clostridium difficile TcdA and TcdB, Shiga toxin Stx2-B, and E. coli endotoxin. Adsorption kinetics were generally best described by the pseudo-second-order model, indicating that the process is governed by chemisorption. Enterosgel also removed small molecules like bile acids (Taurocholic, Glycocholic, Taurochenodeoxycholic, and Glycochenodeoxycholic acids), albeit at a lower capacity than activated carbon, with removal percentages ranging from 1.3% to 27% depending on the compound.

Furthermore, Enterosgel demonstrated moderate adsorption of pharmaceutical drugs such as Cetirizine hydrochloride and Amitriptyline hydrochloride. The results suggest that potential drug interactions can be minimized by maintaining a 2-hour interval between drug and Enterosgel administration.

     Mechanism of Action and Therapeutic Implications

 The primary mechanism of action of Enterosgel is physical adsorption via diffusion into its three-dimensional hydrated polymer network. Its combination of hydrophilic and hydrophobic surface groups allows adsorption of both polar and non-polar substances. By removing bacterial toxins, bile acids, and other gut mediators, Enterosgel may reduce symptoms associated with diarrhoea and gut dysbiosis.

 Conclusion: Potential for Clinical Application

The study provides a comprehensive in vitro evaluation of Enterosgel, confirming its efficacy as an intestinal adsorbent with selective binding properties. While adsorption is lower than that of activated carbon for small molecules, Enterosgel’s targeted adsorption of larger toxins and bile acids supports its use in gastrointestinal therapy. These findings highlight the potential for Enterosgel as a safe and effective therapeutic option for managing diarrhoea and related gastrointestinal disorders, with minimal risk of drug interaction when administered appropriately.

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