Acute Enteric Infections (AEI) remain one of the most serious problems in pediatrics, often leading to complications and poorer prognosis in the absence of adequate initial therapy. The generally accepted foundation of AEI treatment is Enterosorption combined with rehydration, as antibiotics and antiviral drugs are not always effective and may increase intoxication.

The objective of this study was to evaluate the efficacy of using Polymethylsiloxane Polyhydrate in children with AEI compared to other frequently used Enterosorbents.

 Materials, Methods, and Results

A Randomized Prospective Comparative Trial was conducted, including 148 children aged 1 month to 15 years with AEI of various etiologies (Rotavirus Infection, Salmonellosis, etc.). Patients were divided into three comparable groups receiving Polymethylsiloxane Polyhydrate, dioctahedral smectite, or colloidal silicon dioxide/kaolin.

Key Finding: No significant differences were found in the mean duration of the main symptoms of AEI (vomiting, diarrhea) between the group receiving Polymethylsiloxane Polyhydrate and the comparison groups.

Safety and Properties: The drug did not cause any instance of individual intolerance or refusal to take the medication, which is critically important for Infants. It is eliminated completely, does not affect vitamin absorption, and is approved for use from the First Month of Life.

Mechanism of Action: The drug, being a synthetic Enterosorbent, reliably binds toxins, viruses, bacteria, and allergens.

 Conclusion

Polymethylsiloxane Polyhydrate is an Effective and Safe Enterosorbent. Given its comparable efficacy to other popular drugs and superior Organoleptic Properties, it can be recommended as part of combination therapy for AEI in children, including Infants, serving as a valuable alternative in pediatric practice.

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