Acute Intestinal Infections (AII) are the second most common group of infectious diseases in pediatrics. Special attention is paid to cases where AII occur against the background of concomitant conditions such as Atopic Dermatitis (AD). The immune imbalance characteristic of AD can lead to a prolonged course of AII, reduced efficacy of standard therapy, and, conversely, the infection itself can provoke an exacerbation of the allergic process.

This article presents the results of an evaluation of the clinical and laboratory efficacy of modern enterosorbents — diosmectite and polymethylsiloxane polyhydrate (Enterosgel) — in the complex therapy of AII in children with concomitant AD.

Key Study Findings:

High Efficacy: Complex therapy including enterosorbents demonstrated an efficacy level of 88.7–89.7%, which is higher than in the control group without sorbents.

Faster Symptom Relief: The use of sorbents significantly reduces the time required to alleviate symptoms of intoxication (lethargy, reduced appetite) and fever, as well as the duration of the diarrheal syndrome.

Reduced Risk and Severity of AD Exacerbation: The most significant result is that the inclusion of enterosorbents led to a statistically significant 58–63% reduction in the frequency of atopic dermatitis exacerbation.

Skin Condition Improvement: A positive effect on the severity of AD clinical manifestations was noted: the duration of exacerbation was reduced by 3.9–4.8 days, and a significant decrease in the integral SCORAD index (AD severity score) was observed in both mild and moderate cases.

Safety: The study found no side effects or allergic reactions to the tested drugs.

The results demonstrate that the early inclusion of modern enterosorbents in the treatment regimen not only improves prognosis and accelerates recovery from AII but also reduces the risk of exacerbation and decreases the severity of clinical manifestations of the concomitant allergic disease.

Full Article:If you want to see the full data, as well as tables and graphs (including the dynamics of the SCORAD index reduction) , read the full article via the link: Full Article